Immunopeptidomics
Find the antigens that matter, faster
Search immunopeptidomics data with the sensitivity and scale to uncover tumor-specific, non-canonical, and pathogen-derived antigens that standard proteomics pipelines can miss.
Why researchers choose Tesorai for immunopeptidomics
Higher sensitivity and practical turnaround at immunopeptidomics scale.
+60% is vs. all MaxQuant identifications; +136% is vs. the MaxQuant high-confidence subset, indexed separately.
Academic study source: NYU ImmunoVerse study, 21 cancer types (preprint)
More peptide identifications across cancer types
In a large-scale immunopeptidomics study spanning 21 cancer types, Tesorai Search increased peptide identifications by 60% on average compared with the MaxQuant baseline — and by 136% on average among high-confidence identifications.
28,446 tumor-specific HLA-presented antigens identified across 21 cancer types
Actionable tumor-specific targets found in 89% of tumors analyzed
Process massive datasets in hours, not weeks
In collaborator projects, Tesorai has reprocessed some of the largest public immunopeptidomics collections in the field, cutting turnaround from weeks of pipeline time to hours.
2,500 files analyzed in under 5 hours, vs. 8+ weeks with a legacy pipeline — in collaboration with NYU Langone Health & University of Notre Dame
~4,000 files (~4TB) reprocessed in ~7 hours using a custom 100,000-protein search database, in collaboration with Cincinnati Children's Hospital
Capabilities
Built for immunopeptidomics search
Unspecified-cleavage search
Identify HLA-presented peptides without assuming enzymatic cleavage.
Large search spaces
Search expanded protein databases and complex candidate spaces without sacrificing practical turnaround time.
Cohort-scale analysis
Process hundreds or thousands of files without weeks of pipeline time.
Used in large-scale academic research
Tesorai has been used to reprocess large immunopeptidomics collections in academic studies and collaborator projects.
“We extensively leveraged Tesorai to reprocess the public ImmunoVerse immunopeptidomics collection… completing the analysis in approximately 7 hours of total compute time… The superior accuracy of these predictions were reflected in comparison to ours and other prior validation studies.”
— Nathan Salomonis, Salomonis Lab, Cincinnati Children's Hospital
“We used to wait days to process thousands of files. Tesorai finished in just a few hours. It completely changes the pace at which we can operate.”
— Guangyuan (Frank) Li, PhD, NYU Langone Health & University of Notre Dame
Real Results
Sensitivity, speed, and scale
136%
average increase in high-confidence peptide identifications vs. the MaxQuant baseline
28,446
tumor-specific HLA-presented antigens identified across 21 cancer types
~7 hrs
to reprocess a ~4TB / ~4,000-file collection with a 4x-expanded search database, in collaboration with Cincinnati Children's Hospital
See what Tesorai can find in your immunopeptidomics data
Search your own raw MS data with Tesorai.
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